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Course Map: Soft Tissue Tumors: Other Soft Tissue Tumors


Other Soft Tissue Tumors

Malignant fibrous histiocytoma, haemangiopericytoma, osteosarcoma, angiosarcoma, liposarcoma, and malignant extrarenal rhabdoid tumors are rare in the bladder. Of the benign soft tissue tumors, leiomyomas and hemangiomas are the most common. Granular cell tumors and neurofibromas (and ganglioneurofibromas) are rare, the latter occurring usually in patients with von Recklinghausen disease.
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Figure 1: This is a rare malignant fibrous histiocytoma of the bladder. There is a sprinkling of lymphocytes and some large, anaplastic nuclei (arrow). Near the center at the far left (circle), a cluster of cells resembling foamy macrophages, a feature common to many of these lesions.
Figure 2: Malignant fibrous histiocytoma. Same as Figure 1.
Figure 3: Malignant, extrarenal rhabdoid tumor of bladder. The cells all have eccentric nuclei, and prominent nucleoli, and some of them have a discrete, pale zone adjacent to the nucleus (arrows).
Figure 4: Same case as Figure 3, Vimentin immunostain. The cytoplasm of most of the cells is diffusely positive.
Figure 5: Hemangioma of lamina propria. Note that the blood-filled spaces are not "tightly distended" with blood as would be seen with passive vascular congestion.
Figure 6: Figures 6 and 7 are the high and low magnifications of neurofibromas in a case of neurofibromatosis. Narrow strands of collagen with small nuclei (Figure 6) characterize the neurofibromas.
Figure 7: This is a low magnification of Figure 6. Note the nodular character of the lesion.
Figure 8: In a lesion similar to that seen in Figures 6 and 7, the presence of ganglion cells (circle) would make the diagnosis ganglioneurofibroma.