| This refers to those urothelial carcinomas that have areas of
spindled tumor cells. These tumors proliferate as fascicles or storiform
lesions which can mimic various sarcomas or myofibroblastic tumors [13,58,59,109].
In most cases, areas of differentiated carcinoma will be evident, particularly
when highlighted with epithelial markers (cytokeratin or epithelial membrane
antigen). Wide sampling may be required to identify such areas as well as
carcinoma in-situ, which is usually present. These spindle cell neoplasms
could also be regarded as a variant of pure squamous cell carcinoma. In
the bladder, more often than not, this will prove to be the type of differentiated
carcinoma one will find. |
