| In some cases, it is difficult to distinguish between neoplasia
and reactive atypia [45].
There may be greater degrees of pleomorphism and/or hyperchromasia out of
proportion to the degree of inflammation, such that early neoplasia cannot
be ruled out with certainty. Follow-up is indicated for these patients.
Figure 1 compares normal urothelium with atypical urothelium in Figure 2.
Figure 3 contrasts normal and atypical epithelium from the same biopsy.
In neither of these examples is there evident cytologic malignancy nor do
either of them suggest reactive atypia so their malignant potential is uncertain.
|
