Course Map: Epithelial Tumors: Benign: Squamous Papilloma

Squamous Papilloma
In the WHO classification of bladder tumors this designation was used although it will usually be possible to recognize it more specifically as the condyloma acuminatum, particularly when the HPV subtypes 6/11 have been identified by in-situ-hybridization. Many of these will be associated with urethral condylomas and others will occur with long-standing cystotomy, indwelling catheters, or adjacent to fistulas [36,104].
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	Figure 1: A typical condyloma showing a papillary configuration and vacuolated cells (koilocytes)
	Figure 2: Illustration of the morphology of koilocytes: the perinuclear vacuoles often distort nuclear contours, many cells are binucleated(arrows), and, in the lower right center is a brightly eosinophilic, dyskeratotic cell.
	Figure 3: Part of another condyloma.
	Figure 4: Same field as figure 3, showing positivity for HPV 6/11.