Acute suppurative inflammation, appendix

   Observe the normal structures of appendix: mucosa, Submucosa, muscularis and Serosa (Fig.1)

    Destruction of mucosa and purulent exudate are seen focally (Fig.2).

   Inflammation that contains abundant neutrophil is called suppurative or purulent inflammation (Fig.3).

   Neutrophils can be seen in interstitium, lumen and within the epithelium. Extravasation of red blood cells and hemorrhage is also noted (Fig.4),

    Neutrophil infiltration is also present within muscular layer (Fig.5).

    When the inflammation reaches the serosal layer, peritonitis do occur. This pathology  causes localized somatic pain at the site of the appendix (Fig.6).  Suppurative exudate covers the peritoneal surface of the serosa. Neutrophil and fibrinous exudate are noted (Fig.7). In some congested blood vessels, there may be margination of neutrophils (Fig.8).