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Peripheral T-Cell Lymphomas: Example 2B This is a subsequent biopsy from the same patient as Example 2A. Note how the lymphoma has progressed to a more aggressive morphology, both architecturally and cytologically. The atypical T-cell infiltrate involves the entire dermis and (though not seen here) the superficial subcutis. The epidermis is spared, with a pale, uninvolved Grenz zone in the immediately subjacent dermis. A mixture of small and large atypical cells is present. Notice how the lymphoma has progressed from the earlier specimen (Example 2A). The infiltrate is much denser and the cells larger and more atypical. The nuclei of the larger cells are twisted or convoluted rather than oval or cleaved as would be seen in most B-cell lymphomas. Table of Contents