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Mycosis Fungoides The neoplastic T-cells are spread out in a horizontal band just below the epidermal-dermal junction. Other malignant cells infiltrate the epidermis in a manner called "epidermotropic" that is characteristic for cutaneous T-cell lymphomas. Despite all the lymphoid cells infiltrating the epidermis, there is relatively little spongiosis compared to what might be present in a benign inflammatory lesion. The characteristic mycosis fungoides cells are very hyperchromatic and may have nuclei so irregular they are sometimes called "cerebriform". These cells circulate in the blood in a variant called "Sezary's syndrome". In some cases of mycosis fungoides the malignant cells may be larger and more atypical than the ones seen here. Table of Contents