| Event | Mediator of Mechanism |
| Vasodilatation | Histamine, bradykinin, prostaglandins-l2, E2, D2, F2a |
| Increased vascular permeability | Histamine, bradykinin, C3a and C5a (anaphylatoxins), leukotriene C4, D4, E4, PAF, oxygen metabolites |
| Chemotaxis | LTB4, C5a,bacterial products, neutrophil cationic proteins, cytokines (TNF, IL-8) |
| Fever | IL-1, TNF |
| Pain | PGE2, bradykinin |
| Tissue damage | Oxygen free radicals, lysosomal enzymes |