CHEMICAL MEDIATORS
CELLS
Preformed
Histamine
Serotonin
Lysosomal enzyme
Newly synthesized
Prostaglandins
Leukotrienes
Platelet-activating factor
Cytokines
Nitric oxide
PLASMA
Complement activation
C3a
C5a
C5b-9
Hageman factor activation
Kinin system (bradykinin)
Coagulation/fibrinolsis system