Course Map: Epithelial Tumors: Malignant: Urothelial Carcinoma: TNM Classifications

TNM Classifications
pTX	Primary tumor cannot be assessed
pTO	No evidence of primary tumor
pTa	Papillary tumor confined to mucosa. No infiltration of the lamina propria
pTis	Non-papillary, non-infiltrating tumor confined to mucosa--carcinoma in-situ
pT1	Tumor invades subepithelial connective tissue
pT2	Tumor invades muscle pT2a--Tumor invades superficial muscle (inner half) pT2b--Tumor invades deep muscle (outer half)
pT3	Tumor invades perivesical tissue pT3a--Microscopically pT3b--Macroscopically (extravesical mass)
pT4	Tumor invades any of the following: prostate, uterus, vagina, pelvic wall, abdominal wall pT4a--Tumor invades prostate, uterus, or vagina pT4b--Tumor invades pelvic or abdominal wall
N-Regional Lymph Nodes
NX	Regional lymph node cannot be assessed
NO	No regional lymph node metastasis
N1	Metastasis in a single lymph node 2cm or less in greatest dimension
N2	Metastasis in a single lymph node between 2 and 5cm in greatest dimension or inmultiple lymph nodes, none more than 5cm in greatest dimension
N3	Metastasis in a lymph node more than 5cm in greatest dimension
M-Distant Metastasis
MX	Distant metastasis cannot be assessed
MO	No distant metastasis
M1	Distant metastasis
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