| The most common type of glandular metaplasia occurs with proliferative
cystitis, where some of the von Brunn nests are replaced partly or largely
by mucin producing goblet cells identical to those of the colonic type [74,97,111].
Such lesions are designated as cystitis glandularis and the diagnosis
of Figure 1 would be "proliferative cystitis with cystitis glandularis."
Figure 2 shows a florid example of cystitis glandularis and Figure 3 is
similar but there is extensive extravasation of mucin into the adjacent
stroma. Colonic-type metaplasia of surface epithelium is designated "intestinal
metaplasia" [22,33,108],
and it may have a striking resemblance to intestinal mucosa (Figs. 4 and
5). Extensive glandular metaplasia is a significant risk factor for primary
bladder adenocarcinoma, and follow-up is generally indicated [43,92].
|
